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If the NO/cGMP pathway is activated, as occurs with sexual stimulation, inhibition of PDE5 by sildenafil results in amplified corpus cavernosum levels of cGMP . Consequently sexual stimulation is required to ensure that sildenafil to make its meant helpful pharmacological effects .
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an erection that won't go away (priapism). For those who have an erection that lasts over 4 several hours, get medical enable without delay. If It's not handled immediately, priapism can permanently damage your penis.